ABSTRACT
In this case report, we describe the treatment of a young patient with end-stage AIDS, disseminated kaposi sarcoma and COVID-19 infection with molnupravir. With a positive SARS-CoV-2 test, a woman who had never received antiretroviral therapy was admitted to our hospital. On physical examination, multiple small purple maculopapular lesions were present on the body. In the laboratory findings HIV RNA was 255.000 copies, CD4:7 u/L. Tenofovir+ emtricitabine/dolutegravir was started for HIV treatment. Skin biopsy was found to be compatible with Kaposi's sarcoma. The patient's swab every other day was examined for COVID-PCR and remained positive for 63 days. Due to the necessity of oncological treatment, antiviral molnupiravir 2*800 mg treatment was started for 5 days. COVID-PCR performed 4 days after molnupravir treatment and it was negative. We think that early initiation of antiviral treatment is important for PCR negativity and early access to oncological treatment especially in end-stage COVID-positive AIDS cases.
ABSTRACT
OBJECTIVE: We sought to evaluate neurologic symptoms and findings in patients with COVID-19 infection hospitalized in a ward and intensive care unit (ICU). METHODS: This study was designed as a prospective study. Hospitalized COVID-19 rRt-PCR positive patients in the ward and ICU were included in the study. A 54-item questionnaire was used to evaluate the patients. Patients were examined within 3 hours of hospitalization. RESULTS: A total of 379 patients were included in the study. The mean age of the patients was 56.1 ± 17.8. 89 of the patients were in intensive care. At least one general symptom was recorded in 95.5% of patients. The most common neurologic symptoms were myalgia (48.5%), headache (39.6%), anosmia (34.8%), and dysgeusia (34%). Neurological symptoms in ICU patients were higher than in the ward. 53.6% of patients had comorbidities. DISCUSSION: This study indicated that the prevalence of neurological symptoms was very high in patients with COVID-19. The percentage of neurological symptoms and findings was higher in patients hospitalized in ICU.